trRosettaRNA: automated prediction of RNA 3D structure with transformer network

In this work, we developed trRosettaRNA, a deep learning-based RNA structure prediction method. In the blind tests of the 15th Critical Assessment of Structure Prediction (CASP15) and the RNA-Puzzles experiments, the automated trRosettaRNA predictions for the natural RNAs are competitive with the top human predictions. trRosettaRNA also outperforms other deep learning-based methods in CASP15 when measured by the Z-score of the Root-Mean-Square Deviation.

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Reference: Wenkai Wang#, Chenjie Feng#, Renmin Han#, Ziyi Wang, Lisha Ye, Zongyang Du, Hong Wei, Fa Zhang, Zhenling Peng, Jianyi Yang*. "trRosettaRNA: automated prediction of RNA 3D structure with transformer network." Nature Communications. 14: 7266 (2023).